Technology Licensing

Project Leader: Dr Pin Kar Yong

Group Members:

1. Dr. Zamree Md Shah
2. Dr. Pin Kar Yong
3. Khairol Iruwan Abdullah
4. En. Muhammad Yatimi Othman
5. En. Mohd Faizal Arsad
6. Cik Nur Ashmalina Tasnim Mohd Ashraf
7. En. Adib Zubaidi Rashid

The development of Authentic Herbal Extract is initiated to address the common challenges faced by entrepreneurs in purchase of herbal extract. The challenges include:

• Authentic raw material is used in producing extract
• Quality of extract is consistent and guaranteed
• Supporting documents to fulfil the requirements of authority(s)
• Long-term supply is assured

Raw materials received are sent for authentication analysis and quality control (QC) tests in laboratory before being used in production of AHE. Only authenticated and good quality raw materials are used.

AHE is manufactured in extraction facility of Herbal Technology Centre (HTC), FRIM which certified with HACCP and GMP. The production process is conducted by competent personnel following optimised standard operating procedure (SOP). The final product, AHE, is sent for final product quality control (FPQC) tests. The product is only fit for sales if it passes the stringent FPQC tests.

AHE is packed using optimised packaging method to ensure its stability during storage.

Certificate of Analysis is issued and provided together with each batch of AHE.

There are three (3) types of herbal extracts being developed in Herbal Technology Centre, FRIM.

1. Gelenggang Leaf (Senna alata)
2. Tongkat Ali Root (Eurycoma longifolia)
3. Hempedu Bumi Leaf & Stem (Andrographis paniculata)

Project Leader: Dr Fadzureena Jamaludin

Group Members:

1. Dr. Fadzureena Jamaludin
2. Siti Nur Aisyah Hashim
3. Dr. Pin Kar Yong
4. Dr. Zunoliza Abdullah
5. Pn. Hada Masayu Ismail
6. En. Khairul Iruwan Abdullah
7. Dr. Fadhilah Zainudin
8. Mazdiana Mohd Zain
9. Khairul Kamilah Abdul Kadir

Goutree is a brand name for technology developed from research carried out by Forest Research Institute of Malaysia (FRIM) using plant locally known as cucur atap. The plant has been authenticated and its scientific name is Baeckea frutescens. It is a technology to develop a quality, safety and efficacy antigout standardized herbal extract. The extract found is to inhibit the activity of the xanthine oxidase enzyme. This enzyme catalyzes the conversion of xanthine to hypoxanthine and uric acid. High level of uric acid is associated with gout disease. Active and natural compound namely 6-methly quercetin is used as biomarker in the development of the standardized extract to control the quality, safety and efficacy of the technology. Two invention disclosures were filed (ID 1 & 14/2012) with regards all findings in the study. A patent (PI 2014000187) title “An extract of Baeckea frutescens and its use in the treatment of gout” was granted in January 2021.

In the market, the technology can be segment into two types of product:

1. Consumed product- capsule/tablet/syrup
2. Topical application product-spray/cream/balm

Goutree is developed to address the problem faced by gout patients in order to consume or to apply safe, natural and less side effects products or medications.

Project Leader: Dr. Nurhanan Murni Yunos

Group Members:

1. Dr Nurhanan Murni Yunos
2. Muhammad Haffiz Jauri
3. oor Rasyila Mohd Noor
4. Nor Datiakma Mat Amin
5. Dr. Fadzureena Jamaludin
6. Hada Masayu Ismail@Dahlan
7. Nor Jannah Sallehudin
8. Sharmizi Ismail

SEEL30 is an active ingredient in a form of standardised aqueous extract of Tongkat Ali (Eurycoma longifolia) that was prepared under specific conditions in which to retain a specific group of marker and bioactive compounds coded as EL30. Since 2016, data on quality, safety and efficacy have been gathered by Dr Nurhanan and her team to cater the regulatory requirements towards the preparation of low-claim and middle- claim health-based product(s) that incorporates SEEL30.

The quality of SEEL30 is ensured by its chemical fingerprint and EL30 content. The S.O.P. of SEEL30 (FRIM ID21/2018) and its potential usages had been patent filed with MyIPO (UI 2018702577). SEEL30 was scientifically proven to have anti-ovarian cancer property when tested using cancer cell lines (in vitro) and animal model (in vivo).

SEEL30 was also found to have ergogenic property when tested on animal model and the protein target that contribute to the increased in the ATP production had been identified using proteomic analysis. At the moment, Dr Nurhanan and team have prepared prototype products in the forms of capsules and two versions of pre-mix health drinks (chocolate and coffee) that incorporate SEEL30 in these product formulations in which these products are classified respectively as a low-claim and F&B products.

The new market segments for these products may include women, millennial who embrace active and healthy lifestyle and cancer patients who had completed their chemotherapy sessions and undergoing palliative care. Based on their findings, Tongkat Ali (Eurycoma longifolia) has unlimited potential in term of its medicinal properties and applications.

The team keep on doing the R&D on SEEL30 so as to build up more scientific data fordeveloping this active ingredient towards middle- and high-claim products. In the future, they hope to pursue SEEL30 for pre-clinical and clinical trials in human and would welcome for smart collaboration with food or/and health-based industries so that this active ingredient can be part of the treatments for cancer patients.

Project Leader: Saidatul Husni Saidin

Group Members:

1. Saidatul Husni Saidin
2. Mailina Jamil
3. Dr. Zunoliza Abdullah
4. Shalini Markandan
5. Abdul Majid Jalil
6. Dr. Fadhilah Zainudin
7. Syed Othman Syed Omar
8. Khairul Kamilah Abdul Kadir
9. Mazdiana Mohd Zain
10. Dr. Pin Kar Yong

AD, active ingredient for natural skin care products, is originated from Aquilaria sp. standardised extract. The uniqueness of AD is its high quality, safe and proven efficacy with Based on FRIM’s research, Aquilaria sp extract possess free radical scavenging activity and exhibit profound activity of tyrosinase and elastase enzyme inhibition.

These bioactivities indicate the AD has the potential for skin brightening and prevent wrinkling effect. This finding is supported by phytochemical profiling that identifies the presence of mangiferin as a chemical marker and one of the important contributors to the biological activities. AD is considered as non-toxic based on the in-vitro study. AD is in liquid form was formulated for easy to be incorporated into wide range of skin care products. R&D on AD received various innovation awards and recognition at the agencyand national levels.

Project Leader: Dr Mastura Mohtar

1. PDM3 : a unique proprietary mixture of compounds from Aloe vera (aloe) & Camellia sinensis (tea)
2. Notable microbiocidal activity i.e ≥99.99% inhibition against bacteria (including the notorius MRSA), Candida sp, Aspergillus sp. & human corona virus.
3. Non toxic (in vitro & in vivo assays) using normal kidney, hepar cell lines and Sprague Dawley rats.
4. Non corrosive, non bleaching, non flammable, an ideal alternative to problematic germicides exhibiting such attributes.
5. Does not easily vapourized hence minimizing the risk to respiratory system often associated with halogenated (chlorine/fluorine) based products.
6. Ciera® Ecofriendly Multipurpose Disinfectant (CEMPD), a customized PDM3 incorporated disinfectant formulation inhibited 99.99% targeted bacteria, yeast and mould within 10 second exposure time
7. CEMPD – Proven to be non irritant to the skin hence save for the hypersensitive skin.
8. CEMP product solution naturally degrade in the environment (within 5 days). Thus non bio-accumulative as opposed to `triclosan’ (banned or restricted use in countries such as Japan, United Kingdom & Sweden).

   In conclusion, PDM3 the nature inspired microbiocide with its many notableattributes is indeed an ideal germicides for both consumer and environment alike.

Project Leader: Khairol Iruwan Abdullah

Group Members:

1. Dr. Zamree Md Shah
2. Dr Pin Kar Yong
3. Khairol Iruwan Abdullah
4. Adib Zubaidi Rashid
5. Muhammad Yatimi Othman
6. Nur Ashmalina Tasnim Mohd Ashraf
7. Mahmud Husni Abd Hadi

With benefit for general health, Kacip Fatimah herb is parallel with its traditional use for women. To diversify the usage of the herb, a Ready to Drink product is produced using high quality Kacip Fatimah extract with several other ingredients. Taking into consideration of safety, quality and efficacy product, and with high antioxidant and anti-inflammatory activity, the ready to drink is a product which able to boost users’ health. Can be consumed once to twice sachet per day, it is easy to carry and used by women who are busy and having active lifestyle.

Project Leader: Dr Farah Fazwa Md Ariff

Group Members:

1. Dr Farah Fazwa Md Ariff
2. Dr. Fadhilah Zainudin
3. Mazdiana Mohd Zain
4. Syafiqah Nabilah Samsul Bahri
5. Norhayati Saffie
6. Masitah Mohd Taini

Labisia pumila or known as Kacip Fatimah from the Myrsinaceae family is a popular herb species used in Malaysia. Parts of the leaves or whole trees are traditionally used to treat internal problems and women’s health specially to stimulate childbirth, speed up the birth process and postpartum treatment. Other uses of this species are to treat bloating, bloody diarrhea, menstruation, gonorrhea and bone aches. Most of the raw material sources used for the manufacture of herbal products in the market are taken from the forest or in the wild without knowing the genetic quality of the species. This situation will directly affect the quality and quality of the products sold.

Looking at this importance, researchers from the Plant Breeding Program, Forest Research Institute Malaysia (FRIM) led by Dr. Farah Fazwa Md Ariff has conducted research over a period of 10 years for the selection of elite kacip fatimah breeds. These breeds are selected based on good growth characteristics and active chemical content. Total phenolic content or total phenolic content is the main trait as the basis for the selection of the elite Kacip Fatimah breed. This clone has already been registered for Plant Variety Protection (PVP) application under the Department of Agriculture Malaysia under the name FaFaF01.

The FaFaF01 clone also has a high amount of biomass and is easily adaptable to various environmental conditions. Therefore, it is easy to grow on plantations or in greenhouses. Several cultivation models have been developed for the cultivation of FaFaF01 clones to obtain good yield (ROI). It can be grown as a single crop, agroforestry or intercropping. FRIM also has a technology package not only in terms of plant material, but also in breeding, care and cultivation methods that can help the industry for its cultivation. Industries involved in the plantation and production of kacip fatimah-based products can plant FaFaF01 clones to obtain high quality end products.